Sitagliaid M 1000 Tablet

What is Sitagliaid M 1000 Tablet?

Sitagliaid M 1000 Tablet is a combination of two medicines: Sitagliptin and Metformin. This medicine is used in the treatment of type 2 diabetes mellitus. It improves blood glucose levels in adults when taken along with proper diet and regular exercise. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. Sitagliptin inhibits the enzyme DPP4 and increases the release of insulin from the pancreas. This combination is not indicated for patients below 18 years of age.

Can the use of Sitagliaid M 1000 Tablet lead to Vitamin B12 deficiency?

Yes, the use of Sitagliaid M 1000 Tablet can cause Vitamin B12 deficiency on long-term use. It interferes with the absorption of Vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems as a result of which the patient can feel tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in maintaining balance (ataxia). To avoid such problems, some researchers suggest an intake of vitamin B12 from outside sources at least once every year.

What are the possible side effects of Sitagliaid M 1000 Tablet?

The use of Sitagliaid M 1000 Tablet is associated with common side effects like hypoglycemia (low blood sugar level), altered taste, nausea, stomach pain, diarrhea, headache, and upper respiratory tract infection. Its use can also lead to serious but rare side effects like lactic acidosis. On long-term use, it can also lead to Vitamin B12 deficiency.

Are there any specific conditions in which Sitagliaid M 1000 Tablet should not be taken?

The use of Sitagliaid M 1000 Tablet should be avoided in patients with known allergy to any of the components or excipients of this medicine. The use of this medicine should be avoided in patients with severe kidney impairment, liver impairment, congestive heart failure, lactic acidosis, or diabetic ketoacidosis.

Is it safe to take alcohol while I am taking Sitagliaid M 1000 Tablet?

No, it is not safe to take alcohol along with Sitagliaid M 1000 Tablet, as it can increase the chances of lactic acidosis.

What are the instructions for storage and disposal of Sitagliaid M 1000 Tablet?

Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children, and other people.

Can the use of Sitagliaid M 1000 Tablet lead to lactic acidosis?

Yes, the use of Sitagliaid M 1000 Tablet can lead to lactic acidosis. It is a medical emergency which is caused by the increased levels of lactic acid in the blood. It is also known as MALA (Metformin associated lactic acidosis). It is a rare side effect associated with the use of metformin and therefore, it is avoided in patients with underlying kidney disease, old age patients, or who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, feeling of cold in arms and legs, difficulty in breathing, nausea, vomiting, stomach pain, or slow heart rate. If you have these symptoms, stop taking Sitagliptin + Metformin and immediately consult your doctor.